Potentially Prognostic Micro-RNAs in HPV-Associated Oropharyngeal Carcinoma
نویسندگان
چکیده
Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada Division of Biostatistics, Princess Margaret Cancer Center, University Health Network Division of Signaling Biology, Ontario Cancer Institute Department of Pathology, University Health Network Department of Radiation Oncology; Princess Margaret Cancer Center, University Health Network Department of Radiation Oncology; University of Toronto Division of Surgical Oncology, Princess Margaret Cancer Center Division of Medical Oncology, Princess Margaret Cancer Center
منابع مشابه
Human papillomavirus-related small cell carcinoma of the oropharynx.
Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSqCC) represents an important subgroup of head and neck cancer that is characterized by a distinct risk factor profile, a relatively consistent microscopic appearance, and a favorable prognosis. A growing experience with HPV testing of OPSqCCs has uncovered variants that deviate from prototypic HPV-related cancer with r...
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In Head and Neck Squamous Cell Carcinoma, nodal metastasis generally has a negative impact on prognosis. Human Papilloma Virus (HPV)-associated oropharyngeal SCC (OPSCC) has been shown repeatedly to confer better prognoses than HPV-negative oropharyngeal SCC, despite a high frequency of nodal metastases. We hypothesized that nodal metastasis has a reduced impact on survival in HPVpositive OPSCC...
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Identification of human papillomavirus (HPV) as the etiologic agent of cervical cancer has led to its identification in other cancers, with oropharyngeal squamous-cell carcinoma the most common of these.1,2 In this issue of the Journal, Ang and colleagues3 report findings from their study (ClinicalTrials.gov number, NCT00047008) that contribute to the growing body of evidence that HPV-positive ...
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Purpose: Deregulation of miRNAs is associated with almost all human malignancies. Human papillomavirus (HPV)-associated oropharyngeal carcinoma (OPC) has a significantly more favorable outcome compared with HPV-negative OPCs; however, the underlyingmechanisms are not well understood. Hence, the objectives of this studywere to determinewhethermiRNAexpressiondiffered as a functionofHPV status and...
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PURPOSE Deregulation of miRNAs is associated with almost all human malignancies. Human papillomavirus (HPV)-associated oropharyngeal carcinoma (OPC) has a significantly more favorable outcome compared with HPV-negative OPCs; however, the underlying mechanisms are not well understood. Hence, the objectives of this study were to determine whether miRNA expression differed as a function of HPV sta...
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